5 inflammation signs behind depression

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Depression or Neuroinflammation?

Theories about depression and anxiety have changed over the years. Researchers believe that depression, anxiety, and mood problems can have several causes.

Depression caused by inflammation, signs include:

• Problems with sleep

• Fatigue, lack of energy

• Changes in appetite

• Anhedonia - loss of ability to experience pleasure

Cause or Consequence? A significant increase in inflammatory cytokine levels was recorded in some patients with depression. This is interesting, but it's still unclear what came first - the chicken or the egg. Let's investigate!

Five common causes of increased inflammation:

1. Intestinal dysbiosis and increased intestinal wall permeability. A study of patients with major depressive disorder showed that patients have above-average activity of inflammatory markers to fight intestinal bacteria.

2. Autoimmune Diseases and Allergies Many autoimmune diseases, including systemic lupus erythematosus, multiple sclerosis, psoriasis, and rheumatoid arthritis, are associated with increased inflammation. Patients with autoimmune diseases are also at an increased risk of depression. Allergies and asthma can be linked to an increased risk of depression. A meta-analysis calculated that the prevalence of depression in people with rheumatoid arthritis is approximately 39%.

3. Stress can cause physical changes in our bodies. Major life events, such as job loss, death of a loved one, or divorce, cause stress in the body, which can lead to increased pro-inflammatory cytokines.

Our ancestors' stress response was often triggered by physical events, such as an attack by a wild animal. When a stress reaction begins, pro-inflammatory cytokines are activated, which are needed for wound healing. Thus, when a boss yells at you or you're late for a meeting, the body's stress response still triggers an increase in pro-inflammatory cytokines, even if there is no physical wound.

4. Omega-6 to Omega-3 Ratio. Excessive consumption of Omega-6 can increase inflammation. Omega-6 fats are found in soybean, corn, sunflower, and other seed oils. Although Omega-6 fats can be beneficial in small amounts, excessive consumption of Omega-6 oils causes overall inflammation.

Omega-3 fats are found in products like fish and seafood. An increased amount of Omega-3 fats in the diet has an anti-inflammatory effect.

5. Obesity: Increased Inflammation Goes Hand in Hand with Weight Gain Fatty tissue releases inflammatory cytokines, increasing overall inflammation. People with excess weight and depression have, on average, higher inflammation markers than people with normal weight who suffer from depression.

A study reports that people with severe obesity (BMI ≥ 40) are at a much higher risk of depression than people without obesity. It concludes: "The connection between obesity, systemic inflammation, and neuropsychological changes confirms the contribution of inflammatory processes associated with obesity to neuropsychiatric comorbidities in obesity."

Warm regards,
Kos and Helen.