Lion’s Mane: The Mushroom Your Brain Might Thank You For

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What is Lion's Mane?

Meet Lion’s Mane (Hericium erinaceus) A shaggy white mushroom that looks like a brain and may actually support one. Rich in hericenones and erinacines, Lion’s Mane stimulates nerve growth factors. This mushroom may protect neurons from age-related decline.

What the Science Says

Early evidence, real potential

• Boosts neurotrophic factors: Encourages growth and repair of brain cells.

• Reduces inflammation & oxidative stress: Two key drivers of aging.

• Human data: A 16-week clinical trial showed cognitive improvement in older adults taking 750 mg/day.

Bottom Line. Human studies are promising—strong mechanisms, modest clinical proof.

How to Take It

Smart ways to add it to your routine

• Food form: Cook fresh Lion’s Mane (it tastes like crab).

• Supplement form: Choose standardized extracts (fruiting body > mycelium).

• Typical range: 1–3 g/day, or 250 mg 3x daily per clinical studies.

Pro tip: Cycle it for 12–16 weeks, track your mood and focus.

Safety Snapshot

Generally safe, with mild caveats

• Possible mild GI upset or rash.

• Unknown effects in long-term high doses.

• Check with your doctor if you’re on blood thinners or diabetes meds.

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3-Minute Takeaway

1. Supports brain repair & protection.

2. Mechanisms align with anti-aging biology.

3. Works best alongside core longevity habits: sleep, diet, exercise, stress control.

References

• Mori K. et al., Phytotherapy Research (2009): PubMed

• Friedman M. et al., Neurohealth Properties of Hericium erinaceus (2018): PMC

• Calvo-Bonacho E. et al., Antioxidants in Lion's Mane (2022): PMCLorem H1