Your liver’s #1 antioxidant tool

"If we knew what it was we were doing, it would not be called research, would it?" - Albert Einstein.

We changed the name of fatty liver disease to sound smarter. Now it’s time to treat it smarter too. Doctors are finally talking about it: glutathione might be the missing piece in liver health and metabolic repair.

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Killer stats.

Fatty liver disease is becoming increasingly common, with 4 out of 10 American adults now affected, and many don't even suspect this silent threat to their health!

Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat accumulates in your liver without heavy alcohol use. Initially, you might not notice any symptoms. Still, as NAFLD progresses, it will lead to liver inflammation, scarring, even liver failure, and potentially liver cancer. 

A study found that 40.3% of individuals aged 60 to 74 and 39.2% of those over 74 have NAFLD. For those between 60 and 74 years old, NAFLD is linked to a 60% higher risk of all-cause mortality within five years and a 22% higher risk within 10 years.

In 2023, the term NAFLD was replaced with MASLD (metabolic dysfunction-associated steatotic liver disease) to highlight its root cause - metabolic dysfunction more accurately.

Modern understanding of MASLD: more complex than we thought.

We have moved from the old "two-hit hypothesis" to a cascade theory:

• Insulin resistance

• Mitochondrial dysfunction

• Oxidative stress

• Lipid peroxidation destroys membranes

• Ferroptosis activates

• Gut microbiome becomes unbalanced

Glutathione - the protection key we underestimated.

Glutathione (GSH) isn't just one of many antioxidants. This endogenous tripeptide (γ-L-glutamyl-L-cysteinyl-glycine), produced in the liver, acts as the main conductor of the body's oxidation-reduction balance.

Did you know that the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) is a critical marker of oxidative stress?

In healthy tissues, this ratio exceeds 100:1, but during pathological processes, it dramatically falls to 1-10:1!

People with MAFLD have critically low glutathione levels compared to healthy control groups. The severity of the decrease directly relates to the severity of the disease!

Proof of effectiveness.

Working to restore glutathione levels improves biochemical indicators in people with NAFLD. This completely agrees with a review of three studies (109 participants) that showed a significant decrease in ALT after glutathione therapy.

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Glutathione vs. other antioxidants.

Comparative analysis with vitamin E and resveratrol shows several critically important advantages of glutathione:

Vitamin E, according to Sanyal et al.'s study in the New England Journal of Medicine, may increase the risk of hemorrhagic stroke with long-term use - a fact rarely told to patients!

Chalasani et al.'s study (2021) in Hepatology showed that vitamin E improves histological parameters in 43% of patients, while glutathione data indicate comparable and, in some patient groups, even superior effectiveness for inflammation and liver function.

What you need to consider:

1. Bioavailability - a critical issue! Allen and Bradley's study (2019) confirmed that oral intake of standard GSH has extremely limited bioavailability. New delivery forms - liposomal GSH and precursors (N-acetylcysteine) - show much more promising results.

2. Genetic polymorphisms - Mato et al.'s work (2023) sheds light on why some people respond excellently to therapy while others don't. Polymorphisms in the GCLC and GST genes relate to glutathione metabolism.

3. Therapy synergism - the key to success. A recent expert consensus published in the Journal of Hepatology (2024) states that only an integrative approach, combining lifestyle modification, antioxidant support, and targeted pharmacological agents, provides maximum effect in treating MAFLD.

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Helpful strategies to address MASLD at its root, from Dr. Mercola.

Eliminate harmful fats from your diet:
Remove all vegetable oils, including canola, soybean, corn and sunflower oils, from your diet, as they disrupt mitochondrial function and promote inflammation. Instead, use healthier fats like grass-fed tallow, ghee, or butter. Minimize even "healthy" oils like olive oil, as their monounsaturated fat content also impairs metabolic function when consumed excessively.

Optimize your carbohydrate intake:
Aim for a minimum of 200 to 250 grams of targeted carbohydrates daily, adjusting upwards if you are highly active, based on your microbiome.

Balance your protein sources:
Ensure that one-third of your daily protein intake consists of collagen, targeting approximately 0.8 grams of protein per pound of lean body mass, which should make up about 15% of your total calorie intake. Choose grass-fed ruminant meats over conventional chicken or pork to reduce exposure to harmful linoleic acid (LA) and support optimal metabolic health.

Prioritize choline-rich foods:
Choline is important for moving fat out of the liver and lowering the risk of fatty liver disease. Increase your intake of organic, pasture-raised egg yolks, grass-fed beef liver and arugula to increase your intake of this nutrient.

Focus on eating whole, nutrient-dense foods:
Eliminate ultra-processed foods, including fast foods, from your diet, as they're loaded with refined carbohydrates, vegetable oils, preservatives and other harmful ingredients that overwhelm your liver and contribute to dysfunction.

Maintain a healthy weight:
Regular exercise is essential for boosting metabolism and supporting a healthy weight.

Consider taking liver-supporting supplements:
Supporting your liver with targeted nutrients protects against damage and enhances its ability to detoxify and regenerate. Vitamin B12 and folate work together. N-acetylcysteine (NAC), CoQ10, Magnesium. Consider using Glutathione supplements with your specialist.

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From our archive:

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